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ZHAO Lingyun

Associate Professor PhD
E-mail： lyzhao@tsinghua.edu.cn
Address：Yi Fu Science and Technology Building, Rm. B820, Tsinghua University
Dr. Lingyun Zhao, an associate professor at the school of Materials Science and Engineering (MSE) in Tsinghua University. Zhao received her BS and Ms Degrees in Chemical Engineering from Tianjin University in 1995 and 1997, respectively. She obtained her PhD degree in Chemical and Biomelecular Engineering from the National University of Singapore (NUS) in 2004 under the supervision of Prof Feng Si-Shen (Associate editor of Biomaterials, Nanomedicine). She completed her postdoctoral training in the Chemotherapeutic Lab in NUS and then joined Tsinghua University in 2007, firstly in the Institute of Medical Physics and Engineering in the Department of Engineering Physics and then transferred to MSE in July 2014. Her major research interests include cancer nanotechnology, drug delivery, hybrid biomaterials for cancer multimodality treatment and theranostics, ect. She has authored over 100 publications, including peer-reviewed journal papers, book chapters and authored books. She was enlisted by the Elsevier as the “Most Cited Chinese Researcher” (in the division of Biomedical Engineering) from 2014 to 2021.

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Education Background

▪ Ph.D. Department of Chemical & Biomolecular Engineering, National University of Singapore, 1999~2004.

▪ M.Sc. Chemical Engineering, School of Chemical Engineering, Tianjin University, Tianjin, China, 1995-1997.

▪ B.SC. Chemical Engineering, School of Chemical Engineering, Tianjin University, Tianjin, China, 1991-1995.

Work Resume

▪Associate Professor, School of Material Science and Engineering, Tsinghua University 2014~now

▪Associate Professor, Department of Engineering Physics, Tsinghua University 2010~2014

▪Assistant Professor, Department of Engineering Physics, Tsinghua University 2007~2009

▪Research Fellow, Department of Chemical & Biomolecular Engineering, National University of Singapore, 2004~2006

Research Interest

▪ Biomaterials

▪ Cancer Nanotechnology

▪ Functional Materials

Awards And Honors

▪First Prize of Tsinghua University Outstanding Class Advisor in 2024, Tsinghua University

▪ Liu Shuli Education Award, Tsinghua University

▪Scientific and Technological Achievement Award, China Instrument and Control Society

▪Outstanding Postdoctoral Fellow Award, Tsinghua University

▪Gold Award Instructor of the 8th China International "Internet+" College Student Innovation and Entrepreneurship Competition

Selected Research Publications

[1] Guo, Z.; Gao, X.; Lu, J.; Li, Y.; Jin, Z.; Fahad, A.; Pambe, N. U.; Ejima, H.; Sun, X.; Wang, X.; Xie, W.; Zhang, G.; Zhao, L*. Apoptosis and Paraptosis Induced by Disulfiram-Loaded Ca2+/Cu2+ Dual-Ions Nano Trap for Breast Cancer Treatment. ACS Nano 2024, 18 (9), 6975-6989, Article. DOI: 10.1021/acsnano.3c10173.

[2] Xie, W.; Zhang, G.; Guo, Z.; Lu, J.; Ye, J.; Xu, W.; Gao, X.; Yue, K.; Wei, Y.; Zhao, L*. Ultra-Sensitive Iron-Doped Palladium Nanocrystals with Enhanced Hydroxyl Radical Generation for Chemo-/Chemodynamic Nanotherapy. Advanced Functional Materials 2022, 32 (12). DOI: 10.1002/adfm.202107518.

[3] Guo, Z.; Lu, J.; Wang, D.; Xie, W.; Chi, Y.; Xu, J.; Takuya, N.; Zhang, J.; Xu, W.; Gao, F.; Wu, H.; Zhao, L*. Galvanic replacement reaction for in situ fabrication of litchi-shaped heterogeneous liquid metal-Au nano-composite for radio-photothermal cancer therapy. Bioactive Materials 2021, 6 (3), 602-612. DOI: 10.1016/j.bioactmat.2020.08.033.

[4] Lu, J.; Zheng, R.; Shi, Z.; Gao, X.; Li, Y.; Fahad, A.; Ufurahi-Pambe, N.; Jin, Z.; Chen, S.; Xie, W.; Guo, Z.; Yu, J.; Che, S.; Zhang, G.; Xu, B.; Wei, Y.; Zhao, L*. Intracellular Criegee's mechanism-based synergistic ozone therapy mediated by oleogels for cancer treatment. Journal of Controlled Release 2024, 370, 879-890. DOI: 10.1016/j.jconrel.2024.05.039.

[5] Xie, W.; Ye, J.; Guo, Z.; Lu, J.; Xu, W.; Gao, X.; Huang, H.; Hu, R.; Mao, L.; Wei, Y. Zhao, L*. TME-responded Full-biodegradable nanocatalyst for mitochondrial calcium Overload-induced hydroxyl radical bursting cancer treatment. Chemical Engineering Journal 2022, 438, Article. DOI: 10.1016/j.cej.2022.135372.

[6] Guo, Z.; Xie, W.; Zhang, Q.; Lu, J.; Ye, J.; Gao, X.; Xu, W.; Fahad, A.; Xie, Y.; Wei, Y.; Zhao, L*. Photoactivation-triggered in situ self-supplied H2O2for boosting chemodynamic therapy via layered double Hydroxide-mediated catalytic cascade reaction. Chemical Engineering Journal 2022, 446. DOI: 10.1016/j.cej.2022.137310.

[7] Xie, W.; Guo, Z.; Gao, F.; Gao, Q.; Wang, D.; Liaw, B.-s.; Cai, Q.; Sun, X.; Wang, X.; Zhao, L*. Shape-, size- and structure-controlled synthesis and biocompatibility of iron oxide nanoparticles for magnetic theranostics. Theranostics 2018, 8 (12), 3284-3307, Review. DOI: 10.7150/thno.25220.

[8] Guo, Z.; Xie, W.; Lu, J.; Guo, X.; Xu, J.; Xu, W.; Chi, Y.; Takuya, N.; Wu, H.; Zhao, L*. Tannic acid-based metal phenolic networks for bio-applications: a review. Journal of Materials Chemistry B 2021, 9 (20), 4098-4110. DOI: 10.1039/d1tb00383f.